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Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street

BACKGROUND: A strong association of obesity and insulin resistance with increased circulating levels of branched-chain and aromatic amino acids and decreased glycine levels has been recognized in human subjects for decades. SCOPE OF REVIEW: More recently, human metabolomics and genetic studies have...

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Detalles Bibliográficos
Autores principales: White, Phillip J., McGarrah, Robert W., Herman, Mark A., Bain, James R., Shah, Svati H., Newgard, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513145/
https://www.ncbi.nlm.nih.gov/pubmed/34044180
http://dx.doi.org/10.1016/j.molmet.2021.101261