Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway

BACKGROUND: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe complication, which involves pathological damage to the brain and cognitive function. However, its exact mechanism of action still remains unclear. In this study, we explored the role of microglia in the cognitive dysfunct...

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Detalles Bibliográficos
Autores principales: Lu, Li, Wang, Hailin, Liu, Xuan, Tan, Liping, Qiao, Xiaoyue, Ni, Jiali, Sun, Yang, Liang, Jun, Hou, Yayi, Dou, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513209/
https://www.ncbi.nlm.nih.gov/pubmed/34645459
http://dx.doi.org/10.1186/s12974-021-02279-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513209/
https://www.ncbi.nlm.nih.gov/pubmed/34645459
http://dx.doi.org/10.1186/s12974-021-02279-9

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