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Defining matrix Gla protein expression in the Dunkin-Hartley guinea pig model of spontaneous osteoarthritis

BACKGROUND: Matrix Gla (γ-carboxyglutamate) protein (MGP) is considered a strong inhibitor of ectopic calcification, and it has been associated with OA severity, although not conclusively. We utilized male Dunkin-Hartley (DH) guinea pigs to investigate the expression of MGP throughout aging and dise...

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Detalles Bibliográficos
Autores principales: Ma, Xun, Zhang, Zhan, Kang, Xinyuan, Deng, Chunbo, Sun, Yingwei, Li, Yanjun, Huang, Desheng, Liu, Xueyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513366/
https://www.ncbi.nlm.nih.gov/pubmed/34641845
http://dx.doi.org/10.1186/s12891-021-04735-2