Natural and Recombinant SARS-CoV-2 Isolates Rapidly Evolve In Vitro to Higher Infectivity through More Efficient Binding to Heparan Sulfate and Reduced S1/S2 Cleavage

One of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virulence factors is the ability to interact with high affinity to the ACE2 receptor, which mediates viral entry into cells. The results of our study demonstrate that within a few passages in cell culture, both the natural isola...

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Detalles Bibliográficos
Autores principales: Shiliaev, Nikita, Lukash, Tetyana, Palchevska, Oksana, Crossman, David K., Green, Todd J., Crowley, Michael R., Frolova, Elena I., Frolov, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513475/
https://www.ncbi.nlm.nih.gov/pubmed/34406867
http://dx.doi.org/10.1128/JVI.01357-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513475/
https://www.ncbi.nlm.nih.gov/pubmed/34406867
http://dx.doi.org/10.1128/JVI.01357-21

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