An Advanced Automated Patch Clamp Protocol Design to Investigate Drug—Ion Channel Binding Dynamics

Standard high throughput screening projects using automated patch-clamp instruments often fail to grasp essential details of the mechanism of action, such as binding/unbinding dynamics and modulation of gating. In this study, we aim to demonstrate that depth of analysis can be combined with acceptab...

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Detalles Bibliográficos
Autores principales: Lukacs, Peter, Pesti, Krisztina, Földi, Mátyás C., Zboray, Katalin, Toth, Adam V., Papp, Gábor, Mike, Arpad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513526/
https://www.ncbi.nlm.nih.gov/pubmed/34658875
http://dx.doi.org/10.3389/fphar.2021.738260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513526/
https://www.ncbi.nlm.nih.gov/pubmed/34658875
http://dx.doi.org/10.3389/fphar.2021.738260

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