Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration

Fibroblasts are activated to repair the heart following injury. Fibroblast activation in the mammalian heart leads to a permanent fibrotic scar that impairs cardiac function. In other organisms, such as zebrafish, cardiac injury is followed by transient fibrosis and scar-free regeneration. The mecha...

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Detalles Bibliográficos
Autores principales: de Bakker, Dennis E. M., Bouwman, Mara, Dronkers, Esther, Simões, Filipa C., Riley, Paul R., Goumans, Marie-José, Smits, Anke M., Bakkers, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Stem Cells and Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513610/
https://www.ncbi.nlm.nih.gov/pubmed/34486669
http://dx.doi.org/10.1242/dev.198937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513610/
https://www.ncbi.nlm.nih.gov/pubmed/34486669
http://dx.doi.org/10.1242/dev.198937

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