Cargando…

Development and Dynamics of Cytomegalovirus UL97 Ganciclovir Resistance Mutations in Transplant Recipients Detected by Next-Generation Sequencing

BACKGROUND: (Val)ganciclovir resistance mutations in CMV UL97 (UL97-GCV-R) complicate anti-CMV therapy in recipients of solid organ and hematopoietic stem cell transplants, but comprehensive data on prevalence, emergence, and outcome are scarce. METHODS: Using next-generation sequencing (NGS; Illumi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lodding, Isabelle P, Jørgensen, Mette, Bennedbæk, Marc, Kirkby, Nikolai, Naegele, Klaudia, Gustafsson, Finn, Perch, Michael, Rasmussen, Allan, Sengeløv, Henrik, Sørensen, Søren S, Hirsch, Hans H, Lundgren, Jens D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Major Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514173/ https://www.ncbi.nlm.nih.gov/pubmed/34660835 http://dx.doi.org/10.1093/ofid/ofab462

Ejemplares similares

1584. Development and Dynamics of Cytomegalovirus UL97 Ganciclovir Resistance Mutations in Transplant Recipients Detected by Next-generation Sequencing
por: Lodding, Isabelle Paula, et al.
Publicado: (2018)

Cytomegalovirus (CMV) Disease Despite Weekly Preemptive CMV Strategy for Recipients of Solid Organ and Hematopoietic Stem Cell Transplantation
por: Lodding, I P, et al.
Publicado: (2018)

Risk Factors for Failure of Primary (Val)ganciclovir Prophylaxis Against Cytomegalovirus Infection and Disease in Solid Organ Transplant Recipients
por: Khurana, Mark P, et al.
Publicado: (2019)

1597. Risk Factors for Failure of Primary (Val)ganciclovir Prophylaxis Against Cytomegalovirus (CMV) Infection and Disease in Solid Organ Transplant (SOT) Recipients
por: Khurana, Mark Poulsen, et al.
Publicado: (2018)

Analysis of Ganciclovir-Resistant Cytomegalovirus Infection Caused by the UL97 Gene Mutation in Codons 460 and 520 in Pediatric Patients: A Case Series
por: Boonsathorn, Sophida, et al.
Publicado: (2019)

The effects of maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 protein
por: Shannon-Lowe, Claire D, et al.
Publicado: (2010)

Assessment of the Human Cytomegalovirus UL97 Gene for Identification of Resistance to Ganciclovir in Iranian Immunosuppressed Patients
por: Keyvani, Hossein, et al.
Publicado: (2016)

1579. Evaluation of MATCH: an Electronic Individual Patient-Focused Management System Aimed at Preventing Cytomegalovirus Disease Following Solid Organ Transplantation
por: Ekenberg, Christina, et al.
Publicado: (2018)

Impact of CMV PCR Blips in Recipients of Solid Organ and Hematopoietic Stem Cell Transplantation
por: Lodding, Isabelle P., et al.
Publicado: (2018)

Impact of CMV Blips in Transplant Recipients
por: Lodding, Isabelle Paula, et al.
Publicado: (2017)

1079. The Risk of Cytomegalovirus (CMV) Infection and Recurrence Among Solid Organ Transplant Recipients
por: Reekie, Joanne, et al.
Publicado: (2020)

Incidence Rates and Risk Factors of Clostridioides difficile Infection in Solid Organ and Hematopoietic Stem Cell Transplant Recipients
por: Ilett, Emma E, et al.
Publicado: (2019)

Incidence of Ganciclovir Resistance in CMV-positive Renal Transplant Recipients and its Association with UL97 Gene Mutations
por: Aslani, Hamid Reza, et al.
Publicado: (2017)

Clinical Application of Variation in Replication Kinetics During Episodes of Post-transplant Cytomegalovirus Infections
por: Lodding, I.P., et al.
Publicado: (2015)

Human Cytomegalovirus Replication Is Strictly Inhibited by siRNAs Targeting UL54, UL97 or UL122/123 Gene Transcripts
por: Hamilton, Stuart T., et al.
Publicado: (2014)

Serine 13 of the human cytomegalovirus viral cyclin-dependent kinase UL97 is required for regulatory protein 14-3-3 binding and UL97 stability
por: Iwahori, Satoko, et al.
Publicado: (2022)

The Cyclin-Dependent Kinase Ortholog pUL97 of Human Cytomegalovirus Interacts with Cyclins
por: Graf, Laura, et al.
Publicado: (2013)

Cytomegalovirus DNAemia Requiring (Val)Ganciclovir Treatment for More Than 8 Weeks Is a Key Factor in the Development of Antiviral Drug Resistance
por: Acquier, M, et al.
Publicado: (2023)

Clostridium difficile Infection in Solid Organ and Haematopoietic Stem Cell Transplant Recipients
por: Ilett, Emma Elizabeth, et al.
Publicado: (2017)

The Cytomegalovirus Protein Kinase pUL97: Host Interactions, Regulatory Mechanisms and Antiviral Drug Targeting
por: Steingruber, Mirjam, et al.
Publicado: (2020)

Prevalence of UL97 gene mutations and polymorphisms in cytomegalovirus infection in the colon associated with or without ulcerative colitis
por: Tamura, Satoshi, et al.
Publicado: (2021)

Ganciclovir/letermovir: Rebound Cytomegalovirus hepatitis, acquired resistance to ganciclovir and nephrotoxicity: case report
Publicado: (2020)

Recombinant Human Cytomegalovirus Expressing an Analog-Sensitive Kinase pUL97 as Novel Tool for Functional Analyses
por: Krämer, Nadine, et al.
Publicado: (2022)

Ganciclovir-resistant cytomegalovirus infection in renal transplantation
por: Vaz, Raquel, et al.
Publicado: (2014)

The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain
por: Steingruber, Mirjam, et al.
Publicado: (2015)

Incidence of UL97 Resistance Mutations in Infants with Congenital Cytomegalovirus Disease Receiving 6 Months of Oral Valganciclovir Therapy
por: James, Scott H, et al.
Publicado: (2017)

Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97
por: Milbradt, Jens, et al.
Publicado: (2018)

Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97
por: Schütz, Martin, et al.
Publicado: (2021)

Presumed neonatal cytomegalovirus retinitis treated with intravenous ganciclovir
por: Suganya, A, et al.
Publicado: (2020)

Preemptive ganciclovir for mechanically ventilated patients with cytomegalovirus reactivation
por: Papazian, Laurent, et al.
Publicado: (2021)

1075. Absolute Lymphocyte Count as a Predictor of Cytomegalovirus (CMV) Infection and Recurrence in Hematopoietic Stem Cell Transplant (HSCT) Recipients
por: Reekie, Joanne, et al.
Publicado: (2020)

Proteomic Interaction Patterns between Human Cyclins, the Cyclin-Dependent Kinase Ortholog pUL97 and Additional Cytomegalovirus Proteins
por: Steingruber, Mirjam, et al.
Publicado: (2016)

Functional characterization of novel mutations in UL54 of ganciclovir resistant HCMV strain using structural analysis
por: Malathi, Jambulingam, et al.
Publicado: (2011)

Treatment outcomes of reduced-dose intravitreal ganciclovir for cytomegalovirus retinitis
por: Choopong, Pitipol, et al.
Publicado: (2016)

Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection
por: Natale, Fabio, et al.
Publicado: (2015)

Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir
por: Gill, Rachel B, et al.
Publicado: (2009)

Human cytomegalovirus pUL97 upregulates SOCS3 expression via transcription factor RFX7 in neural progenitor cells
por: Wang, Xian-Zhang, et al.
Publicado: (2023)

The Human Cytomegalovirus UL76 Gene Regulates the Level of Expression of the UL77 Gene
por: Isomura, Hiroki, et al.
Publicado: (2010)

The Role of the Human Cytomegalovirus UL133-UL138 Gene Locus in Latency and Reactivation
por: Mlera, Luwanika, et al.
Publicado: (2020)

Characterization of the transcripts of human cytomegalovirus UL144
por: He, Rong, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_851lev4chcc4504ehfbhbg6rm9