Cargando…

Multifunctional Antibodies Are Induced by the RTS,S Malaria Vaccine and Associated With Protection in a Phase 1/2a Trial

BACKGROUND: RTS,S is the leading malaria vaccine candidate but only confers partial efficacy against malaria in children. RTS,S is based on the major Plasmodium falciparum sporozoite surface antigen, circumsporozoite protein (CSP). The induction of anti-CSP antibodies is important for protection; ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kurtovic, Liriye, Atre, Tanmaya, Feng, Gaoqian, Wines, Bruce D, Chan, Jo-Anne, Boyle, Michelle J, Drew, Damien R, Hogarth, P Mark, Fowkes, Freya J I, Bergmann-Leitner, Elke S, Beeson, James G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Major Articles and Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514181/ https://www.ncbi.nlm.nih.gov/pubmed/32236404 http://dx.doi.org/10.1093/infdis/jiaa144

Ejemplares similares

Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children
por: Feng, Gaoqian, et al.
Publicado: (2022)

Induction and decay of functional complement-fixing antibodies by the RTS,S malaria vaccine in children, and a negative impact of malaria exposure
por: Kurtovic, Liriye, et al.
Publicado: (2019)

Mechanisms and targets of Fcγ-receptor mediated immunity to malaria sporozoites
por: Feng, Gaoqian, et al.
Publicado: (2021)

Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
por: Beeson, James G., et al.
Publicado: (2016)

Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children
por: Kurtovic, Liriye, et al.
Publicado: (2018)

Antibody Targets and Properties for Complement-Fixation Against the Circumsporozoite Protein in Malaria Immunity
por: Kurtovic, Liriye, et al.
Publicado: (2021)

Novel Virus-Like Particle Vaccine Encoding the Circumsporozoite Protein of Plasmodium falciparum Is Immunogenic and Induces Functional Antibody Responses in Mice
por: Kurtovic, Liriye, et al.
Publicado: (2021)

Differential Homing Receptor Profiles of Lymphocytes Induced by Attenuated versus Live Plasmodium falciparum Sporozoites
por: Mura, Marie, et al.
Publicado: (2022)

Recent clinical trials inform the future for malaria vaccines
por: Kurtovic, Liriye, et al.
Publicado: (2021)

Complement in malaria immunity and vaccines
por: Kurtovic, Liriye, et al.
Publicado: (2019)

Effect of the Pre-erythrocytic Candidate Malaria Vaccine RTS,S/AS01(E) on Blood Stage Immunity in Young Children
por: Bejon, Philip, et al.
Publicado: (2011)

Immunoprofiling Identifies Functional B and T Cell Subsets Induced by an Attenuated Whole Parasite Malaria Vaccine as Correlates of Sterile Immunity
por: Mura, Marie, et al.
Publicado: (2022)

The Anti-Circumsporozoite Antibody Response of Children to Seasonal Vaccination With the RTS,S/AS01(E) Malaria Vaccine( )
por: Sagara, Issaka, et al.
Publicado: (2021)

Complement Factors in COVID-19 Therapeutics and Vaccines
por: Kurtovic, Liriye, et al.
Publicado: (2021)

A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01(E) and RTS,S/AS01(B) Delayed Fractional Dose Regimens in Malaria-Naive Adults
por: Moon, James E, et al.
Publicado: (2020)

The association between naturally acquired IgG subclass specific antibodies to the PfRH5 invasion complex and protection from Plasmodium falciparum malaria
por: Weaver, Rupert, et al.
Publicado: (2016)

The biological function of antibodies induced by the RTS,S/AS01 malaria vaccine candidate is determined by their fine specificity
por: Chaudhury, Sidhartha, et al.
Publicado: (2016)

Novel sporozoite-based ELISpot assay to assess frequency of parasite-specific B cells after vaccination with irradiated sporozoites
por: Atre, Tanmaya, et al.
Publicado: (2019)

Research priorities for the development and implementation of serological tools for malaria surveillance
por: Elliott, Salenna R., et al.
Publicado: (2014)

Combining immunoprofiling with machine learning to assess the effects of adjuvant formulation on human vaccine-induced immunity
por: Chaudhury, Sidhartha, et al.
Publicado: (2019)

RTS,S: the first malaria vaccine
por: Zavala, Fidel
Publicado: (2022)

Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates
por: Chan, Jo-Anne, et al.
Publicado: (2014)

Delayed fractional dose regimen of the RTS,S/AS01 malaria vaccine candidate enhances an IgG4 response that inhibits serum opsonophagocytosis
por: Chaudhury, Sidhartha, et al.
Publicado: (2017)

Declining Transmission and Immunity to Malaria and Emerging Artemisinin Resistance in Thailand: A Longitudinal Study
por: Ataíde, Ricardo, et al.
Publicado: (2017)

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2
por: Wines, Bruce D., et al.
Publicado: (2022)

The thermostability of the RTS,S/AS01 malaria vaccine can be increased by co-lyophilizing RTS,S and AS01
por: Fortpied, Juliette, et al.
Publicado: (2020)

Corrigendum: Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2
por: Wines, Bruce D., et al.
Publicado: (2023)

New Insights into Acquisition, Boosting, and Longevity of Immunity to Malaria in Pregnant Women
por: Fowkes, Freya JI., et al.
Publicado: (2012)

Implications of the licensure of a partially efficacious malaria vaccine on evaluating second-generation vaccines
por: Fowkes, Freya JI, et al.
Publicado: (2013)

RTS,S Malaria Vaccine and Increased Mortality in Girls
por: Klein, Sabra L., et al.
Publicado: (2016)

Identification of Immune Signatures of Novel Adjuvant Formulations Using Machine Learning
por: Chaudhury, Sidhartha, et al.
Publicado: (2018)

Evaluation of RTS,S/AS02A and RTS,S/AS01B in Adults in a High Malaria Transmission Area
por: Polhemus, Mark E., et al.
Publicado: (2009)

Targets of complement-fixing antibodies in protective immunity against malaria in children
por: Reiling, Linda, et al.
Publicado: (2019)

The RTS,S malaria vaccine: Journey from conception to recommendation
por: Egbewande, Oluwaseyi Muyiwa
Publicado: (2022)

High Antibodies to VAR2CSA in Response to Malaria Infection Are Associated With Improved Birthweight in a Longitudinal Study of Pregnant Women
por: McLean, Alistair R. D., et al.
Publicado: (2021)

Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01(B) With Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP
por: Rampling, Tommy, et al.
Publicado: (2016)

The Relationship between Anti-merozoite Antibodies and Incidence of Plasmodium falciparum Malaria: A Systematic Review and Meta-analysis
por: Fowkes, Freya J. I., et al.
Publicado: (2010)

Policy analysis for deciding on a malaria vaccine RTS,S in Tanzania
por: Romore, Idda, et al.
Publicado: (2016)

The Future of the RTS,S/AS01 Malaria Vaccine: An Alternative Development Plan
por: Gosling, Roly, et al.
Publicado: (2016)

Implementation strategies for the introduction of the RTS,S/AS01 (RTS,S) malaria vaccine in countries with areas of highly seasonal transmission: workshop meeting report
por: Merle, Corinne S.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4mh17siafgs22pkgu6japqcbfb