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Disulfide-compatible phage-assisted continuous evolution in the periplasmic space
The directed evolution of antibodies has yielded important research tools and human therapeutics. The dependence of many antibodies on disulfide bonds for stability has limited the application of continuous evolution technologies to antibodies and other disulfide-containing proteins. Here we describ...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514426/ https://www.ncbi.nlm.nih.gov/pubmed/34645844 http://dx.doi.org/10.1038/s41467-021-26279-8 |