Cargando…
Prefused lysosomes cluster on autophagosomes regulated by VAMP8
Lysosome–autophagosome fusion is critical to autophagosome maturation. Although several proteins that regulate this fusion process have been identified, the prefusion architecture and its regulation remain unclear. Herein, we show that upon stimulation, multiple lysosomes form clusters around indivi...
Autores principales: | Chen, Qixin, Hao, Mingang, Wang, Lei, Li, Linsen, Chen, Yang, Shao, Xintian, Tian, Zhiqi, Pfuetzner, Richard A., Zhong, Qing, Brunger, Axel T., Guan, Jun-Lin, Diao, Jiajie |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514493/ https://www.ncbi.nlm.nih.gov/pubmed/34645799 http://dx.doi.org/10.1038/s41419-021-04243-0 |
Ejemplares similares
-
Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
por: Diao, Jiajie, et al.
Publicado: (2013) -
The Longin SNARE VAMP7/TI-VAMP Adopts a Closed Conformation
por: Vivona, Sandro, et al.
Publicado: (2010) -
mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation
por: Huang, Hong, et al.
Publicado: (2021) -
A dual-labeling probe to track functional mitochondria–lysosome interactions in live cells
por: Chen, Qixin, et al.
Publicado: (2020) -
Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts
por: Qiu, Kangqiang, et al.
Publicado: (2022)