Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression

The acidic tumor microenvironment in melanoma drives immune evasion by up-regulating cyclic adenosine monophosphate (cAMP) in tumor-infiltrating monocytes. Here we show that the release of non-toxic concentrations of an adenylate cyclase (AC) inhibitor from poly(sarcosine)-block-poly(L-glutamic acid...

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Detalles Bibliográficos
Autores principales: Johann, Kerstin, Bohn, Toszka, Shahneh, Fatemeh, Luther, Natascha, Birke, Alexander, Jaurich, Henriette, Helm, Mark, Klein, Matthias, Raker, Verena K., Bopp, Tobias, Barz, Matthias, Becker, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514514/
https://www.ncbi.nlm.nih.gov/pubmed/34645812
http://dx.doi.org/10.1038/s41467-021-26269-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514514/
https://www.ncbi.nlm.nih.gov/pubmed/34645812
http://dx.doi.org/10.1038/s41467-021-26269-w

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