In vivo evaluation of GG2–GG1/A2 element activity in the insulin promoter region using the CRISPR–Cas9 system

The insulin promoter is regulated by ubiquitous as well as pancreatic β-cell-specific transcription factors. In the insulin promoter, GG2–GG1/A2–C1 (bases − 149 to − 116 in the human insulin promoter) play important roles in regulating β-cell-specific expression of the insulin gene. However, these e...

Descripción completa

Detalles Bibliográficos
Autores principales: Noguchi, Hirofumi, Miyagi-Shiohira, Chika, Kinjo, Takao, Saitoh, Issei, Watanabe, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514523/
https://www.ncbi.nlm.nih.gov/pubmed/34645928
http://dx.doi.org/10.1038/s41598-021-99808-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514523/
https://www.ncbi.nlm.nih.gov/pubmed/34645928
http://dx.doi.org/10.1038/s41598-021-99808-6

Ejemplares similares