Phorbol-12-myristate 13-acetate inhibits Nephronectin gene expression via Protein kinase C alpha and c-Jun/c-Fos transcription factors

Nephronectin (Npnt) is an extracellular matrix protein and ligand of integrin α(8)β(1) known to promote differentiation of osteoblasts. A search for factors that regulate Npnt gene expression in osteoblasts revealed that phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC),...

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Detalles Bibliográficos
Autores principales: Kinoshita, Mitsuhiro, Yamada, Atsushi, Sasa, Kiyohito, Ikezaki, Kaori, Shirota, Tatsuo, Kamijo, Ryutaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514542/
https://www.ncbi.nlm.nih.gov/pubmed/34645824
http://dx.doi.org/10.1038/s41598-021-00034-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514542/
https://www.ncbi.nlm.nih.gov/pubmed/34645824
http://dx.doi.org/10.1038/s41598-021-00034-x

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