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Evaluation of anorexia and analysis of related factors in patients with COVID-19
OBJECTIVE: COVID-19 may cause an anorexic situation. This in turn leads to underfeeding, puts the patient in an energy protein malnutrition state, develops the hyperinflammation, weakens the immunity, and makes COVID-19 conditions more dangerous. Meanwhile, the more severe inflammation conditions in...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Société francophone nutrition clinique et métabolisme (SFNCM). Published by Elsevier Masson SAS.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514646/ http://dx.doi.org/10.1016/j.nupar.2021.08.001 |
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author | Shahbazi, Shaahin Hajimohammadebrahim-Ketabforoush, Melika Vahdat Shariatpanahi, Maryam Shahbazi, Erfan Vahdat Shariatpanahi, Zahra |
author_facet | Shahbazi, Shaahin Hajimohammadebrahim-Ketabforoush, Melika Vahdat Shariatpanahi, Maryam Shahbazi, Erfan Vahdat Shariatpanahi, Zahra |
author_sort | Shahbazi, Shaahin |
collection | PubMed |
description | OBJECTIVE: COVID-19 may cause an anorexic situation. This in turn leads to underfeeding, puts the patient in an energy protein malnutrition state, develops the hyperinflammation, weakens the immunity, and makes COVID-19 conditions more dangerous. Meanwhile, the more severe inflammation conditions in the body, the more severe the anorexia, which in turn affect the disease severity. Studies evaluating appetite in COVID-19 patients are very rare; therefore, we evaluated anorexia and analyzed the related factors in patients with COVID-19. MATERIAL AND METHODS: In this cross sectional study, adult patients’ ≥18 years old with the positive real-time fluorescence polymerase chain reaction for COVID-19 were included. The patients were classified as mild, moderate, and severe based on the WHO classification. We measured the appetite score, weight, height, body mass index (BMI), depression and anxiety score, at admission for every patient. RESULTS: A total of 301 patients participated in the study. The prevalence of admission anorexia was 58%, and this rate was significantly more in the severe group compared to the mild and moderate groups (P < 0.001). Comorbidities, depression and anxiety were independently correlated with anorexia risk [(OR = 3.6, 95% CI 1.68–7.70, P = 0.001), (OR = 1.23, 95% CI 1.16–1.30, P < 0001), and (OR = 1.24, 95% CI 1.17–1.31, P < 0001)], respectively. This correlation was adherence to a U-shape association for BMI, which means BMI < 18.5 (OR = 3.35, 95% CI 1.8–10.42, P < 0001) and BMI ≥30 (OR = 2.45, 95% CI 1.02–6.53, P = 0.048) were related to higher risk of anorexia. CONCLUSION: We reported a high prevalence of anorexia (58%) in COVID-19 patients, which was positively correlated with disease severity. Furthermore, any factor worsening inflammatory state, including underweight, obesity, comorbidities, depression and anxiety can exacerbate anorexia in these patients. |
format | Online Article Text |
id | pubmed-8514646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Société francophone nutrition clinique et métabolisme (SFNCM). Published by Elsevier Masson SAS. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85146462021-10-14 Evaluation of anorexia and analysis of related factors in patients with COVID-19 Shahbazi, Shaahin Hajimohammadebrahim-Ketabforoush, Melika Vahdat Shariatpanahi, Maryam Shahbazi, Erfan Vahdat Shariatpanahi, Zahra Nutrition Clinique et Me´tabolisme Original Article OBJECTIVE: COVID-19 may cause an anorexic situation. This in turn leads to underfeeding, puts the patient in an energy protein malnutrition state, develops the hyperinflammation, weakens the immunity, and makes COVID-19 conditions more dangerous. Meanwhile, the more severe inflammation conditions in the body, the more severe the anorexia, which in turn affect the disease severity. Studies evaluating appetite in COVID-19 patients are very rare; therefore, we evaluated anorexia and analyzed the related factors in patients with COVID-19. MATERIAL AND METHODS: In this cross sectional study, adult patients’ ≥18 years old with the positive real-time fluorescence polymerase chain reaction for COVID-19 were included. The patients were classified as mild, moderate, and severe based on the WHO classification. We measured the appetite score, weight, height, body mass index (BMI), depression and anxiety score, at admission for every patient. RESULTS: A total of 301 patients participated in the study. The prevalence of admission anorexia was 58%, and this rate was significantly more in the severe group compared to the mild and moderate groups (P < 0.001). Comorbidities, depression and anxiety were independently correlated with anorexia risk [(OR = 3.6, 95% CI 1.68–7.70, P = 0.001), (OR = 1.23, 95% CI 1.16–1.30, P < 0001), and (OR = 1.24, 95% CI 1.17–1.31, P < 0001)], respectively. This correlation was adherence to a U-shape association for BMI, which means BMI < 18.5 (OR = 3.35, 95% CI 1.8–10.42, P < 0001) and BMI ≥30 (OR = 2.45, 95% CI 1.02–6.53, P = 0.048) were related to higher risk of anorexia. CONCLUSION: We reported a high prevalence of anorexia (58%) in COVID-19 patients, which was positively correlated with disease severity. Furthermore, any factor worsening inflammatory state, including underweight, obesity, comorbidities, depression and anxiety can exacerbate anorexia in these patients. Société francophone nutrition clinique et métabolisme (SFNCM). Published by Elsevier Masson SAS. 2022-02 2021-10-14 /pmc/articles/PMC8514646/ http://dx.doi.org/10.1016/j.nupar.2021.08.001 Text en © 2021 Société francophone nutrition clinique et métabolisme (SFNCM). Published by Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Shahbazi, Shaahin Hajimohammadebrahim-Ketabforoush, Melika Vahdat Shariatpanahi, Maryam Shahbazi, Erfan Vahdat Shariatpanahi, Zahra Evaluation of anorexia and analysis of related factors in patients with COVID-19 |
title | Evaluation of anorexia and analysis of related factors in patients with COVID-19 |
title_full | Evaluation of anorexia and analysis of related factors in patients with COVID-19 |
title_fullStr | Evaluation of anorexia and analysis of related factors in patients with COVID-19 |
title_full_unstemmed | Evaluation of anorexia and analysis of related factors in patients with COVID-19 |
title_short | Evaluation of anorexia and analysis of related factors in patients with COVID-19 |
title_sort | evaluation of anorexia and analysis of related factors in patients with covid-19 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514646/ http://dx.doi.org/10.1016/j.nupar.2021.08.001 |
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