Poor CD4(+) T Cell Immunogenicity Limits Humoral Immunity to P. falciparum Transmission-Blocking Candidate Pfs25 in Humans

Plasmodium falciparum transmission-blocking vaccines (TBVs) targeting the Pfs25 antigen have shown promise in mice but the same efficacy has never been achieved in humans. We have previously published pre-clinical data related to a TBV candidate Pfs25-IMX313 encoded in viral vectors which was very p...

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Detalles Bibliográficos
Autores principales: Zaric, Marija, Marini, Arianna, Nielsen, Carolyn M., Gupta, Gaurav, Mekhaiel, David, Pham, Thao P., Elias, Sean C., Taylor, Iona J., de Graaf, Hans, Payne, Ruth O., Li, Yuanyuan, Silk, Sarah E., Williams, Chris, Hill, Adrian V. S., Long, Carole A., Miura, Kazutoyo, Biswas, Sumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515144/
https://www.ncbi.nlm.nih.gov/pubmed/34659219
http://dx.doi.org/10.3389/fimmu.2021.732667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515144/
https://www.ncbi.nlm.nih.gov/pubmed/34659219
http://dx.doi.org/10.3389/fimmu.2021.732667

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