Effects of Distal Mutations on Ligand-Binding Affinity in E. coli Dihydrofolate Reductase

[Image: see text] Mutations far from the center of chemical activity in dihydrofolate reductase (DHFR) can affect several steps in the catalytic cycle. Mutations at highly conserved positions and the distal distance of the catalytic center (Met-42, Thr-113, and Gly-121) were designed, including sing...

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Detalles Bibliográficos
Autores principales: Huang, Chen-Hua, Chen, Yun-Wen, Huang, Tsun-Tsao, Kao, Ya-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515367/
https://www.ncbi.nlm.nih.gov/pubmed/34660967
http://dx.doi.org/10.1021/acsomega.1c02995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515367/
https://www.ncbi.nlm.nih.gov/pubmed/34660967
http://dx.doi.org/10.1021/acsomega.1c02995

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