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Effects of Distal Mutations on Ligand-Binding Affinity in E. coli Dihydrofolate Reductase
[Image: see text] Mutations far from the center of chemical activity in dihydrofolate reductase (DHFR) can affect several steps in the catalytic cycle. Mutations at highly conserved positions and the distal distance of the catalytic center (Met-42, Thr-113, and Gly-121) were designed, including sing...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515367/ https://www.ncbi.nlm.nih.gov/pubmed/34660967 http://dx.doi.org/10.1021/acsomega.1c02995 |