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Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial

OBJECTIVE: To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. DESIGN: Randomised controlled, adaptive, open label clinical trial. SETTING: 28 hospitals in Brazil, Canada, Ireland, Saudi Arabia, Uni...

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Autores principales: Sholzberg, Michelle, Tang, Grace H, Rahhal, Hassan, AlHamzah, Musaad, Kreuziger, Lisa Baumann, Áinle, Fionnuala Ní, Alomran, Faris, Alayed, Khalid, Alsheef, Mohammed, AlSumait, Fahad, Pompilio, Carlos Eduardo, Sperlich, Catherine, Tangri, Sabrena, Tang, Terence, Jaksa, Peter, Suryanarayan, Deepa, Almarshoodi, Mozah, Castellucci, Lana A, James, Paula D, Lillicrap, David, Carrier, Marc, Beckett, Andrew, Colovos, Christos, Jayakar, Jai, Arsenault, Marie-Pier, Wu, Cynthia, Doyon, Karine, Andreou, E Roseann, Dounaevskaia, Vera, Tseng, Eric K, Lim, Gloria, Fralick, Michael, Middeldorp, Saskia, Lee, Agnes Y Y, Zuo, Fei, da Costa, Bruno R, Thorpe, Kevin E, Negri, Elnara Márcia, Cushman, Mary, Jüni, Peter, Laupacis, Andreas, Lin, Yulia, Day, Andrew, Rochwerg, Bram, Abdulrehman, Jameel, Gergi, Mansour, Kondo, Rodrigo Hidd, Piloto, Bruna Mamprim, de Abreu Pereira, Guilherme, Valente, Fernando Salvetti, Agreda, Ariel Fernando Villarroel, Munoz Torres, Pablo Andres, Moraes, Maíra Oliveira, de Lucena Moreira, Claudia, Neto, Fernando Galassi Stocco, Baptista, Fabíola Vieira Duarte, Moreira, Joanne Alves, Ferreira, Augusto Séttemo, Frudit, Paula, Martinez, Gabriel, Souza, Heraldo Possolo, Neto, Rodrigo Antônio Brandão, d'Amico, Elbio Antonio, Padrão, Eduardo Messias Hirano, Sarin da Mota e Albuquerque, Fernando, Zangrossi, Giovanna Villela, Kanasiro, Alberto Kendy, Cincoto, Alissom Vitti, de Souza Reis, Hugo, Arias da Silva, Vitor Miyashiro, Bellintani, Arthur Petrillo, dos Santos Pereira, Vivian, de Oliveira, Yohan Washington, Carvalho, Bárbara Justo, de Souza Novaes, Mariana, Silveira, Henrique Brito, de Avelar, Gabriel César Alves, Mota, Lara Bonanni, Caciola, Karina, Marim, Matheus de Arêa Leão Freire, Monsalvarga, Tales Cabral, Blanco Santos, Alexandre Salgado, Haydar, Ahmed, Saraiva, Gabriella Seixas Sampaio, da Costa Ribeiro, Sabrina Correa, Meirelles Marchini, Julio Flavio, de Alencar, Julio Cesar Garcia, de Seixas Santos, Ana Catharina, Millette, Caroline, Lebeau, Mathieu, Devaux, Céline, Boutin, Mélina, Nguyen, Trung Nghia, Srour, Line, de Angelis, Flavia, Fugulin, Mariane, Binnie, Alexandra, Bejaimal, Shayna A.D., Binding, Andrew, Marticorena, Rosa M., Ginocchio, Galo, Kaplovitch, Eric, Rymaszewski, Klaudia, Raissi, Afsaneh, Falappa, Marcelo, Ernst, Blair, Ali, Amna, Romano, Martin, Khurram, Mobina, Kim, Christie, Kapur, Ajay, Edwards, Michelle, Swarup, Vidushi, Camilotti, Bruna, Jani, Jiten, Carter, Jeff, Gillrie, Mark R., Sidhu, Davinder, Robinson, Traci, Stutely, Krystina, Watpool, Irene, Porteous, Rebecca, Jao, Kevin, Boudreault-Pedneault, Jean-Samuel, Kandel, Christopher, Taylor, Maureen T., Choo, Wei En Enoch, Parsons, Laura, Dowbenka, Ann, Ramonas, Gitana, Nikitin, Sergey, Patterson, Jeffery, Hnatiuk, Mark, Tapardel, Anca, Lapner, Sarah Takach, Carpenter, Thirza, Rackel, Lori, Cairns, Rebecca, Pinder, Jessica, Anglin, Peter, McPherson, Catherine, Chiverton, Liselle, Barbosa, David, Loukiantchenko, Shany, Shamiss, Yana, Tassy, Danaë, Shivakumar, Sudeep, Keating, Mary-Margaret, Pleasance, Sue, Kevane, Barry, Cullivan, Sarah, Power, Nick, Doran, Peter, Leamy, Kelly, Kelly, Aoife, Moran, Conor, O'Connor, Mairead, McDonnell, Aoife, Boyce, Roseanne, Sefroun, Faiza, Hussain, Rabia, Murray, Patrick, Malara, Anna, Molloy, Brenda, O’Halloran, Meadbh, Cunningham, Emer, Lambert, Jack, Cotter, Aoife, Marsh, Brian, Sheehan, Gerard, Muldoon, Eavan, Woo, James, Gaine, Sean, Morley, Deirdre, AlGahtani, Farjah H, Almaghlouth, Ibrahim, Ata, Sondus, Alkhathlan, Fai, Khalil, Najma, Hussein, Israa Mohamed, Bashir, Mohammed, BaHammam, Ahmed S, Alsultan, Abdulrahman, Alkofide, Hadeel, Alhawassi, Tariq M, Alqahtani, Abdulhadi M., Zayed, Emad K., AlSughayir, Ammar, Abuzied, Yacoub, AlZahrani, Hazzaa, Al-Otaibi, Jawaher, Alothaimeen, Haya, Alzannan, Noura, Al Homssi, Amer, Abid, Haisam, Jones, Stephanie, Broaddrick, Shannon, Jain, Neha, King, Roz, Jindal, Mohit, Sanfilippo, Kristen, Nieters, Patty, Hammad, Muhammad, Benny, Aleeswa Francis, Hamdan, Tariq A., Elobaid, Suhaib Kamal Ahmed, Khafagi, Ibrahim, Ahmed, Saima Saeed, AlEssaie, AbduleRehman, AlAlawi, Shamma, Bashir, Khloud, Al Suwaidi, Aysha Abdulla Salem, Ahmed, Hiba Ibrahim Khogali, Ismail, Mohamed Milad, El Faki, El Mutasim Ahmed, Charles, Mercy, Dang, Alice, Lakhanpal, Gurpreet, Lee, Dominic, Ray, Prachi, Naydenova, Maria, Wysocki, Kosma, Jiwajee, Aziz, Wendling, Greg, Boyle, Rebekah, Cornell, Elaine, Mukaz, Debora Kamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515466/
https://www.ncbi.nlm.nih.gov/pubmed/34649864
http://dx.doi.org/10.1136/bmj.n2400