Novel Double-Modified Colchicine Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, and Biological Activity Evaluation

[Image: see text] A series of 1,4-disubstituted 1,2,3-triazoles having 10-demethoxy-10-N-methylaminocolchicine core were designed and synthesized via the Cu(I)-catalyzed “click” reaction and screened for their in vitro cytotoxicity against four cancer cell lines (A549, MCF-7, LoVo, LoVo/DX) and one...

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Detalles Bibliográficos
Autores principales: Krzywik, Julia, Nasulewicz-Goldeman, Anna, Mozga, Witold, Wietrzyk, Joanna, Huczyński, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515607/
https://www.ncbi.nlm.nih.gov/pubmed/34661013
http://dx.doi.org/10.1021/acsomega.1c03948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515607/
https://www.ncbi.nlm.nih.gov/pubmed/34661013
http://dx.doi.org/10.1021/acsomega.1c03948

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