U2 snRNA structure is influenced by SF3A and SF3B proteins but not by SF3B inhibitors

U2 snRNP is an essential component of the spliceosome. It is responsible for branch point recognition in the spliceosome A-complex via base-pairing of U2 snRNA with an intron to form the branch helix. Small molecule inhibitors target the SF3B component of the U2 snRNP and interfere with A-complex fo...

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Detalles Bibliográficos
Autores principales: Urabe, Veronica K., Stevers, Meredith, Ghosh, Arun K., Jurica, Melissa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516221/
https://www.ncbi.nlm.nih.gov/pubmed/34648557
http://dx.doi.org/10.1371/journal.pone.0258551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516221/
https://www.ncbi.nlm.nih.gov/pubmed/34648557
http://dx.doi.org/10.1371/journal.pone.0258551

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