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The CRL4(VPRBP(DCAF1)) E3 ubiquitin ligase directs constitutive RAG1 degradation in a non-lymphoid cell line
The development of B and T lymphocytes critically depends on RAG1/2 endonuclease activity to mediate antigen receptor gene assembly by V(D)J recombination. Although control of RAG1/2 activity through cell cycle- and ubiquitin-dependent degradation of RAG2 has been studied in detail, relatively littl...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516306/ https://www.ncbi.nlm.nih.gov/pubmed/34648572 http://dx.doi.org/10.1371/journal.pone.0258683 |