An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development

We developed an Xrcc4(M61R) separation of function mouse line to overcome the embryonic lethality of Xrcc4-deficient mice. XRCC4(M61R) protein does not interact with Xlf, thus obliterating XRCC4-Xlf filament formation while preserving the ability to stabilize DNA ligase IV. X4(M61R) mice, which are...

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Detalles Bibliográficos
Autores principales: Roch, Benoit, Abramowski, Vincent, Etienne, Olivier, Musilli, Stefania, David, Pierre, Charbonnier, Jean-Baptiste, Callebaut, Isabelle, Boussin, François D, de Villartay, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516412/
https://www.ncbi.nlm.nih.gov/pubmed/34519267
http://dx.doi.org/10.7554/eLife.69353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516412/
https://www.ncbi.nlm.nih.gov/pubmed/34519267
http://dx.doi.org/10.7554/eLife.69353

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