Antiviral Activity and Pharmacokinetics of the Hepatitis B Virus (HBV) Capsid Assembly Modulator GLS4 in Patients With Chronic HBV Infection

BACKGROUND: GLS4 is a first-in-class hepatitis B virus (HBV) capsid assembly modulator (class I) that can inhibit HBV replication by interfering with the assembly and disassembly of HBV nucleocapsid. Here, we evaluated its antiviral activity, pharmacokinetics, and tolerability in a double-blind, ran...

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Detalles Bibliográficos
Autores principales: Zhang, Hong, Wang, Fengjiao, Zhu, Xiaoxue, Chen, Yunfu, Chen, Hong, Li, Xiaojiao, Wu, Min, Li, Cuiyun, Liu, Jingrui, Zhang, Yingjun, Ding, Yanhua, Niu, Junqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Major Articles and Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516514/
https://www.ncbi.nlm.nih.gov/pubmed/32649736
http://dx.doi.org/10.1093/cid/ciaa961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516514/
https://www.ncbi.nlm.nih.gov/pubmed/32649736
http://dx.doi.org/10.1093/cid/ciaa961

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