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Spontaneous and inherited TP53 genetic alterations
The p53 protein is a transcription factor that prevents tumors from developing. In spontaneous and inherited cancers there are many different missense mutations in the DNA binding domain of the TP53 gene that contributes to tumor formation. These mutations produce a wide distribution in the transcri...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516647/ https://www.ncbi.nlm.nih.gov/pubmed/34389799 http://dx.doi.org/10.1038/s41388-021-01991-3 |