Quantification of kappa opioid receptor ligand potency, efficacy and desensitization using a real-time membrane potential assay

We explored the utility of the real-time FLIPR Membrane Potential (FMP) assay as a method to assess kappa opioid receptor (KOR)-induced hyperpolarization. The FMP Blue dye was used to measure fluorescent signals reflecting changes in membrane potential in KOR expressing CHO (CHO-KOR) cells. Treatmen...

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Detalles Bibliográficos
Autores principales: Zhao, Yuanzi, Joshi, Anand A., Aldrich, Jane V., Murray, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516733/
https://www.ncbi.nlm.nih.gov/pubmed/34536757
http://dx.doi.org/10.1016/j.biopha.2021.112173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516733/
https://www.ncbi.nlm.nih.gov/pubmed/34536757
http://dx.doi.org/10.1016/j.biopha.2021.112173

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