An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection

It is urgent to develop disease models to dissect mechanisms regulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we derive airway organoids from human pluripotent stem cells (hPSC-AOs). The hPSC-AOs, particularly ciliated-like cells, are permissive to SARS-CoV-2...

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Detalles Bibliográficos
Autores principales: Duan, Xiaohua, Tang, Xuming, Nair, Manoj S., Zhang, Tuo, Qiu, Yunping, Zhang, Wei, Wang, Pengfei, Huang, Yaoxing, Xiang, Jenny, Wang, Hui, Schwartz, Robert E., Ho, David D., Evans, Todd, Chen, Shuibing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516798/
https://www.ncbi.nlm.nih.gov/pubmed/34731648
http://dx.doi.org/10.1016/j.celrep.2021.109920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516798/
https://www.ncbi.nlm.nih.gov/pubmed/34731648
http://dx.doi.org/10.1016/j.celrep.2021.109920

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