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INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants
Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccin...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516974/ https://www.ncbi.nlm.nih.gov/pubmed/34650089 http://dx.doi.org/10.1038/s41541-021-00384-7 |
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| author | Andrade, Viviane M. Christensen-Quick, Aaron Agnes, Joseph Tur, Jared Reed, Charles Kalia, Richa Marrero, Idania Elwood, Dustin Schultheis, Katherine Purwar, Mansi Reuschel, Emma McMullan, Trevor Pezzoli, Patrick Kraynyak, Kim Sylvester, Albert Mammen, Mammen P. Tebas, Pablo Joseph Kim, J. Weiner, David B. Smith, Trevor R. F. Ramos, Stephanie J. Humeau, Laurent M. Boyer, Jean D. Broderick, Kate E. |
| author_facet | Andrade, Viviane M. Christensen-Quick, Aaron Agnes, Joseph Tur, Jared Reed, Charles Kalia, Richa Marrero, Idania Elwood, Dustin Schultheis, Katherine Purwar, Mansi Reuschel, Emma McMullan, Trevor Pezzoli, Patrick Kraynyak, Kim Sylvester, Albert Mammen, Mammen P. Tebas, Pablo Joseph Kim, J. Weiner, David B. Smith, Trevor R. F. Ramos, Stephanie J. Humeau, Laurent M. Boyer, Jean D. Broderick, Kate E. |
| author_sort | Andrade, Viviane M. |
| collection | PubMed |
| description | Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all variants tested. |
| format | Online Article Text |
| id | pubmed-8516974 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-85169742021-10-29 INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants Andrade, Viviane M. Christensen-Quick, Aaron Agnes, Joseph Tur, Jared Reed, Charles Kalia, Richa Marrero, Idania Elwood, Dustin Schultheis, Katherine Purwar, Mansi Reuschel, Emma McMullan, Trevor Pezzoli, Patrick Kraynyak, Kim Sylvester, Albert Mammen, Mammen P. Tebas, Pablo Joseph Kim, J. Weiner, David B. Smith, Trevor R. F. Ramos, Stephanie J. Humeau, Laurent M. Boyer, Jean D. Broderick, Kate E. NPJ Vaccines Brief Communication Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all variants tested. Nature Publishing Group UK 2021-10-14 /pmc/articles/PMC8516974/ /pubmed/34650089 http://dx.doi.org/10.1038/s41541-021-00384-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Brief Communication Andrade, Viviane M. Christensen-Quick, Aaron Agnes, Joseph Tur, Jared Reed, Charles Kalia, Richa Marrero, Idania Elwood, Dustin Schultheis, Katherine Purwar, Mansi Reuschel, Emma McMullan, Trevor Pezzoli, Patrick Kraynyak, Kim Sylvester, Albert Mammen, Mammen P. Tebas, Pablo Joseph Kim, J. Weiner, David B. Smith, Trevor R. F. Ramos, Stephanie J. Humeau, Laurent M. Boyer, Jean D. Broderick, Kate E. INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants |
| title | INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants |
| title_full | INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants |
| title_fullStr | INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants |
| title_full_unstemmed | INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants |
| title_short | INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants |
| title_sort | ino-4800 dna vaccine induces neutralizing antibodies and t cell activity against global sars-cov-2 variants |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516974/ https://www.ncbi.nlm.nih.gov/pubmed/34650089 http://dx.doi.org/10.1038/s41541-021-00384-7 |
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