Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment

Adeno-associated viruses (AAVs) are widely used to deliver genetic material in vivo to distinct cell types such as neurons or glial cells, allowing for targeted manipulation. Transduction of microglia is mostly excluded from this strategy, likely due to the cells’ heterogeneous state upon environmen...

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Detalles Bibliográficos
Autores principales: Maes, Margaret E., Wögenstein, Gabriele M., Colombo, Gloria, Casado-Polanco, Raquel, Siegert, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516996/
https://www.ncbi.nlm.nih.gov/pubmed/34703843
http://dx.doi.org/10.1016/j.omtm.2021.09.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516996/
https://www.ncbi.nlm.nih.gov/pubmed/34703843
http://dx.doi.org/10.1016/j.omtm.2021.09.006

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