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Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment
Adeno-associated viruses (AAVs) are widely used to deliver genetic material in vivo to distinct cell types such as neurons or glial cells, allowing for targeted manipulation. Transduction of microglia is mostly excluded from this strategy, likely due to the cells’ heterogeneous state upon environmen...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516996/ https://www.ncbi.nlm.nih.gov/pubmed/34703843 http://dx.doi.org/10.1016/j.omtm.2021.09.006 |