Minimal impact of ZAP on lentiviral vector production and transduction efficiency

The antiviral protein ZAP binds CpG dinucleotides in viral RNA to inhibit replication. This has likely led to the CpG suppression observed in many RNA viruses, including retroviruses. Sequences added to retroviral vector genomes, such as internal promoters, transgenes, or regulatory elements, substa...

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Detalles Bibliográficos
Autores principales: Sertkaya, Helin, Hidalgo, Laura, Ficarelli, Mattia, Kmiec, Dorota, Signell, Adrian W., Ali, Sadfer, Parker, Hannah, Wilson, Harry, Neil, Stuart J.D., Malim, Michael H., Vink, Conrad A., Swanson, Chad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517000/
https://www.ncbi.nlm.nih.gov/pubmed/34703838
http://dx.doi.org/10.1016/j.omtm.2021.08.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517000/
https://www.ncbi.nlm.nih.gov/pubmed/34703838
http://dx.doi.org/10.1016/j.omtm.2021.08.008

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