Optimization of AAV6 transduction enhances site-specific genome editing of primary human lymphocytes

Adeno-associated virus serotype 6 (AAV6) is a valuable reagent for genome editing of hematopoietic cells due to its ability to serve as a homology donor template. However, a comprehensive study of AAV6 transduction of hematopoietic cells in culture, with the goal of maximizing ex vivo genome editing...

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Detalles Bibliográficos
Autores principales: Rogers, Geoffrey L., Huang, Chun, Clark, Robert D.E., Seclén, Eduardo, Chen, Hsu-Yu, Cannon, Paula M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517001/
https://www.ncbi.nlm.nih.gov/pubmed/34703842
http://dx.doi.org/10.1016/j.omtm.2021.09.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517001/
https://www.ncbi.nlm.nih.gov/pubmed/34703842
http://dx.doi.org/10.1016/j.omtm.2021.09.003

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