PIP(2)-dependent coupling of voltage sensor and pore domains in K(v)7.2 channel

Phosphatidylinositol-4,5-bisphosphate (PIP(2)) is a signaling lipid which regulates voltage-gated K(v)7/KCNQ potassium channels. Altered PIP(2) sensitivity of neuronal K(v)7.2 channel is involved in KCNQ2 epileptic encephalopathy. However, the molecular action of PIP(2) on K(v)7.2 gating remains lar...

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Detalles Bibliográficos
Autores principales: Pant, Shashank, Zhang, Jiaren, Kim, Eung Chang, Lam, Kin, Chung, Hee Jung, Tajkhorshid, Emad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517023/
https://www.ncbi.nlm.nih.gov/pubmed/34650221
http://dx.doi.org/10.1038/s42003-021-02729-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517023/
https://www.ncbi.nlm.nih.gov/pubmed/34650221
http://dx.doi.org/10.1038/s42003-021-02729-3

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