The tyrosine-kinase inhibitor Nintedanib ameliorates autosomal-dominant polycystic kidney disease

Autosomal-dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease and is characterized by progressive growth of fluid-filled cysts. Growth factors binding to receptor tyrosine kinases (RTKs) stimulate cell proliferation and cyst growth in PKD. Nintedanib, a triple RTK...

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Detalles Bibliográficos
Autores principales: Jamadar, Abeda, Suma, Sreenath M., Mathew, Sijo, Fields, Timothy A., Wallace, Darren P., Calvet, James P., Rao, Reena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517027/
https://www.ncbi.nlm.nih.gov/pubmed/34650051
http://dx.doi.org/10.1038/s41419-021-04248-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517027/
https://www.ncbi.nlm.nih.gov/pubmed/34650051
http://dx.doi.org/10.1038/s41419-021-04248-9

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