Analysis of M4 Transmembrane Segments in NMDA Receptor Function: A Negative Allosteric Modulatory Site at the GluN1 M4 is Determining the Efficiency of Neurosteroid Modulation

Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that play a crucial role in excitatory synaptic transmission in the central nervous system. Each subunit contributes with three helical transmembrane segments (M1, M3, and M4) and a pore loop (M2) to form the channel po...

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Detalles Bibliográficos
Autores principales: Langer, Kai, Müller-Längle, Adriana, Wempe, Jannik, Laube, Bodo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517087/
https://www.ncbi.nlm.nih.gov/pubmed/34658899
http://dx.doi.org/10.3389/fphar.2021.769046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517087/
https://www.ncbi.nlm.nih.gov/pubmed/34658899
http://dx.doi.org/10.3389/fphar.2021.769046

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