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Methylation of the tyrosine hydroxylase gene is dysregulated by cocaine dependence in the human striatum
Cocaine dependence is a chronic, relapsing disorder caused by lasting changes in the brain. Animal studies have identified cocaine-related alterations in striatal DNA methylation; however, it is unclear how methylation is related to cocaine dependence in humans. We generated methylomic profiles of t...
Autores principales: | Vaillancourt, Kathryn, Chen, Gang G., Fiori, Laura, Maussion, Gilles, Yerko, Volodymyr, Théroux, Jean-François, Ernst, Carl, Labonté, Benoit, Calipari, Erin, Nestler, Eric J., Nagy, Corina, Mechawar, Naguib, Mash, Deborah C., Turecki, Gustavo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517202/ https://www.ncbi.nlm.nih.gov/pubmed/34693223 http://dx.doi.org/10.1016/j.isci.2021.103169 |
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