Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2

Human trophoblast cell surface antigen 2 (TROP-2) is an important target of tumor therapy, and antibody-drug conjugates with sacituzumab targeting TROP-2 have been approved for the treatment of triple-negative breast cancer. Here, we report the crystal structures of TROP-2-ECD, which can be either c...

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Detalles Bibliográficos
Autores principales: Sun, Meng, Zhang, Helin, Jiang, Min, Chai, Yan, Qi, Jianxun, Gao, George F., Tan, Shuguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517388/
https://www.ncbi.nlm.nih.gov/pubmed/34693228
http://dx.doi.org/10.1016/j.isci.2021.103190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517388/
https://www.ncbi.nlm.nih.gov/pubmed/34693228
http://dx.doi.org/10.1016/j.isci.2021.103190

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