An Integrated Mass Spectrometry and Molecular Dynamics Simulations Approach Reveals the Spatial Organization Impact of Metal-Binding Sites on the Stability of Metal-Depleted Metallothionein-2 Species

[Image: see text] Mammalian metallothioneins (MTs) are a group of cysteine-rich proteins that bind metal ions in two α- and β-domains and represent a major cellular Zn(II)/Cu(I) buffering system in the cell. At cellular free Zn(II) concentrations (10(–11)–10(–9) M), MTs do not exist in fully loaded...

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Detalles Bibliográficos
Autores principales: Peris-Díaz, Manuel David, Guran, Roman, Domene, Carmen, de los Rios, Vivian, Zitka, Ondrej, Adam, Vojtech, Krężel, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517974/
https://www.ncbi.nlm.nih.gov/pubmed/34477370
http://dx.doi.org/10.1021/jacs.1c05495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517974/
https://www.ncbi.nlm.nih.gov/pubmed/34477370
http://dx.doi.org/10.1021/jacs.1c05495

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