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An Optimized Chemical-Genetic Method for Cell-Specific Metabolic Labeling of RNA
Tissues and organs are composed of diverse cell types, which poses a major challenge for cell-specific gene expression profiling. Current metabolic labeling methods rely on the inability of mammalian cells to incorporate exogenous pyrimidine analogs, which are then co-opted by ectopically-expressed...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518020/ https://www.ncbi.nlm.nih.gov/pubmed/32015544 http://dx.doi.org/10.1038/s41592-019-0726-y |