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Three‐level hybrid modeling for systematic optimization of biocatalytic synthesis: α‐glucosyl glycerol production by enzymatic trans‐glycosylation from sucrose

Mechanism‐based kinetic models are rigorous tools to analyze enzymatic reactions, but their extension to actual conditions of the biocatalytic synthesis can be difficult. Here, we demonstrate (mechanistic‐empirical) hybrid modeling for systematic optimization of the sucrose phosphorylase‐catalyzed g...

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Detalles Bibliográficos
Autores principales: Sigg, Alexander, Klimacek, Mario, Nidetzky, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518044/
https://www.ncbi.nlm.nih.gov/pubmed/34232503
http://dx.doi.org/10.1002/bit.27878