Efficient Entropy‐Driven Inhibition of Dipeptidyl Peptidase III by Hydroxyethylene Transition‐State Peptidomimetics

Dipeptidyl peptidase III (DPP3) is a ubiquitously expressed Zn‐dependent protease, which plays an important role in regulating endogenous peptide hormones, such as enkephalins or angiotensins. In previous biophysical studies, it could be shown that substrate binding is driven by a large entropic con...

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Detalles Bibliográficos
Autores principales: Ivkovic, Jakov, Jha, Shalinee, Lembacher‐Fadum, Christian, Puschnig, Johannes, Kumar, Prashant, Reithofer, Viktoria, Gruber, Karl, Macheroux, Peter, Breinbauer, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518066/
https://www.ncbi.nlm.nih.gov/pubmed/34314529
http://dx.doi.org/10.1002/chem.202102204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518066/
https://www.ncbi.nlm.nih.gov/pubmed/34314529
http://dx.doi.org/10.1002/chem.202102204

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