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Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation
BACKGROUND: Alternative cleavage and polyadenylation (APA), an RNA processing event, occurs in over 70% of human protein-coding genes. APA results in mRNA transcripts with distinct 3′ ends. Most APA occurs within 3′ UTRs, which harbor regulatory elements that can impact mRNA stability, translation,...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518154/ https://www.ncbi.nlm.nih.gov/pubmed/34649612 http://dx.doi.org/10.1186/s13059-021-02502-z |