Utrophin modulator drugs as potential therapies for Duchenne and Becker muscular dystrophies

Utrophin is an autosomal paralogue of dystrophin, a protein whose deficit causes Duchenne and Becker muscular dystrophies (DMD/BMD). Utrophin is naturally overexpressed at the sarcolemma of mature dystrophin‐deficient fibres in DMD and BMD patients as well as in the mdx Duchenne mouse model. Dystrop...

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Detalles Bibliográficos
Autores principales: Soblechero‐Martín, Patricia, López‐Martínez, Andrea, de la Puente‐Ovejero, Laura, Vallejo‐Illarramendi, Ainara, Arechavala‐Gomeza, Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518368/
https://www.ncbi.nlm.nih.gov/pubmed/33999469
http://dx.doi.org/10.1111/nan.12735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518368/
https://www.ncbi.nlm.nih.gov/pubmed/33999469
http://dx.doi.org/10.1111/nan.12735

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