From Quinoline to Quinazoline‐Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search

Antibiotic resistance breakers, such as efflux pump inhibitors (EPIs), represent a powerful alternative to the development of new antimicrobials. Recently, by using previously described EPIs, we developed pharmacophore models able to identify inhibitors of NorA, the most studied efflux pump of Staph...

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Detalles Bibliográficos
Autores principales: Cedraro, Nicholas, Cannalire, Rolando, Astolfi, Andrea, Mangiaterra, Gianmarco, Felicetti, Tommaso, Vaiasicca, Salvatore, Cernicchi, Giada, Massari, Serena, Manfroni, Giuseppe, Tabarrini, Oriana, Cecchetti, Violetta, Barreca, Maria Letizia, Biavasco, Francesca, Sabatini, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518402/
https://www.ncbi.nlm.nih.gov/pubmed/34032014
http://dx.doi.org/10.1002/cmdc.202100282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518402/
https://www.ncbi.nlm.nih.gov/pubmed/34032014
http://dx.doi.org/10.1002/cmdc.202100282

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