N‐(Anilinoethyl)amide Melatonergic Ligands with Improved Water Solubility and Metabolic Stability

The MT(2)‐selective melatonin receptor ligand UCM765 (N‐(2‐((3‐methoxyphenyl)(phenyl)amino)ethyl)acetamide), showed interesting sleep inducing, analgesic and anxiolytic properties in rodents, but suffers from low water solubility and modest metabolic stability. To overcome these limitations, differe...

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Detalles Bibliográficos
Autores principales: Ferlenghi, Francesca, Mari, Michele, Gobbi, Gabriella, Elisi, Gian Marco, Mor, Marco, Rivara, Silvia, Vacondio, Federica, Bartolucci, Silvia, Bedini, Annalida, Fanini, Fabiola, Spadoni, Gilberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518537/
https://www.ncbi.nlm.nih.gov/pubmed/34213063
http://dx.doi.org/10.1002/cmdc.202100405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518537/
https://www.ncbi.nlm.nih.gov/pubmed/34213063
http://dx.doi.org/10.1002/cmdc.202100405

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