Effects of TPMT, NUDT15, and ITPA Genetic Variants on 6-Mercaptopurine Toxicity for Pediatric Patients With Acute Lymphoblastic Leukemia in Yunnan of China

Background: 6-Mercaptopurine (6-MP) is the cornerstone of current antileukemia regimen and contributes greatly to improve the survival of pediatric acute lymphoblastic leukemia (ALL) patients. However, 6-MP dose-related toxicities limit its application. TPMT, NUDT15, and ITPA are pharmacogenetic mar...

Descripción completa

Detalles Bibliográficos
Autores principales: Mao, Xiaoyan, Yin, Runxiu, Sun, Gaoyuan, Zhou, Yan, Yang, Chunhui, Fang, Chunlian, Wu, Yuhong, Cui, Tingting, Liu, Li, Gan, Jiaxin, Tian, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518605/
https://www.ncbi.nlm.nih.gov/pubmed/34660484
http://dx.doi.org/10.3389/fped.2021.719803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518605/
https://www.ncbi.nlm.nih.gov/pubmed/34660484
http://dx.doi.org/10.3389/fped.2021.719803

Ejemplares similares