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Effects of TPMT, NUDT15, and ITPA Genetic Variants on 6-Mercaptopurine Toxicity for Pediatric Patients With Acute Lymphoblastic Leukemia in Yunnan of China

Background: 6-Mercaptopurine (6-MP) is the cornerstone of current antileukemia regimen and contributes greatly to improve the survival of pediatric acute lymphoblastic leukemia (ALL) patients. However, 6-MP dose-related toxicities limit its application. TPMT, NUDT15, and ITPA are pharmacogenetic mar...

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Detalles Bibliográficos
Autores principales:	Mao, Xiaoyan, Yin, Runxiu, Sun, Gaoyuan, Zhou, Yan, Yang, Chunhui, Fang, Chunlian, Wu, Yuhong, Cui, Tingting, Liu, Li, Gan, Jiaxin, Tian, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pediatrics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518605/ https://www.ncbi.nlm.nih.gov/pubmed/34660484 http://dx.doi.org/10.3389/fped.2021.719803

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