Alpha Synuclein only Forms Fibrils In Vitro when Larger than its Critical Size of 70 Monomers

The aggregation of α‐synuclein into small soluble aggregates and then fibrils is important in the development and spreading of aggregates through the brain in Parkinson's disease. Fibrillar aggregates can grow by monomer addition and then break into fragments that could spread into neighboring...

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Detalles Bibliográficos
Autores principales: Sanchez, Santiago Enrique, Whiten, Daniel R., Meisl, Georg, Ruggeri, Francesco Simone, Hidari, Eric, Klenerman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518629/
https://www.ncbi.nlm.nih.gov/pubmed/34383993
http://dx.doi.org/10.1002/cbic.202100285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518629/
https://www.ncbi.nlm.nih.gov/pubmed/34383993
http://dx.doi.org/10.1002/cbic.202100285

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