METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes

The methylase METTL3 is the writer enzyme of the N(6)‐methyladenosine (m(6)A) modification of RNA. Using a structure‐based drug discovery approach, we identified a METTL3 inhibitor with potency in a biochemical assay of 280 nM, while its enantiomer is 100 times less active. We observed a dose‐depend...

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Detalles Bibliográficos
Autores principales: Moroz‐Omori, Elena V., Huang, Danzhi, Kumar Bedi, Rajiv, Cheriyamkunnel, Sherry J., Bochenkova, Elena, Dolbois, Aymeric, Rzeczkowski, Maciej D., Li, Yaozong, Wiedmer, Lars, Caflisch, Amedeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518639/
https://www.ncbi.nlm.nih.gov/pubmed/34237194
http://dx.doi.org/10.1002/cmdc.202100291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518639/
https://www.ncbi.nlm.nih.gov/pubmed/34237194
http://dx.doi.org/10.1002/cmdc.202100291

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