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METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes
The methylase METTL3 is the writer enzyme of the N(6)‐methyladenosine (m(6)A) modification of RNA. Using a structure‐based drug discovery approach, we identified a METTL3 inhibitor with potency in a biochemical assay of 280 nM, while its enantiomer is 100 times less active. We observed a dose‐depend...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518639/ https://www.ncbi.nlm.nih.gov/pubmed/34237194 http://dx.doi.org/10.1002/cmdc.202100291 |