Cargando…

Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms

BACKGROUND AND PURPOSE: Neurosteroids influence neuronal function and have multiple promising clinical applications. Direct modulation of postsynaptic neurotransmitter receptors by neurosteroids is well characterized, but presynaptic effects remain poorly understood. Here, we report presynaptic glut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smejkalova, Tereza, Korinek, Miloslav, Krusek, Jan, Hrcka Krausova, Barbora, Candelas Serra, Miriam, Hajdukovic, Dragana, Kudova, Eva, Chodounska, Hana, Vyklicky, Ladislav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518729/ https://www.ncbi.nlm.nih.gov/pubmed/33988248 http://dx.doi.org/10.1111/bph.15529

Ejemplares similares

The Neuroactive Steroid Pregnanolone Glutamate: Anticonvulsant Effect, Metabolites and Its Effect on Neurosteroid Levels in Developing Rat Brains
por: Kudova, Eva, et al.
Publicado: (2021)

Cholesterol modulates presynaptic and postsynaptic properties of excitatory synaptic transmission
por: Korinek, Miloslav, et al.
Publicado: (2020)

Overview of the Molecular Steps in Steroidogenesis of the GABAergic Neurosteroids Allopregnanolone and Pregnanolone
por: Liang, Jennifer J., et al.
Publicado: (2018)

Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit
por: Vyklicky, Vojtech, et al.
Publicado: (2018)

Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule
por: Vyklicky, Vojtech, et al.
Publicado: (2015)

Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia
por: Holubova, Kristina, et al.
Publicado: (2021)

Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif
por: Adla, Santosh Kumar, et al.
Publicado: (2018)

Pregnanolone Glutamate, a Novel Use-Dependent NMDA Receptor Inhibitor, Exerts Antidepressant-Like Properties in Animal Models
por: Holubova, Kristina, et al.
Publicado: (2014)

Behavioral effects of triazolam and pregnanolone combinations: reinforcing and sedative-motor effects in female rhesus monkeys
por: Cook, Jemma E., et al.
Publicado: (2023)

Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study
por: Rustichelli, Cecilia, et al.
Publicado: (2021)

BV-2 Microglial Cells Respond to Rotenone Toxic Insult by Modifying Pregnenolone, 5α-Dihydroprogesterone and Pregnanolone Levels
por: Avallone, Rossella, et al.
Publicado: (2020)

Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABA(A) Receptor γ2 Subunit in the Cerebellum
por: Leppä, Elli, et al.
Publicado: (2016)

The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate
por: Ladislav, Marek, et al.
Publicado: (2018)

Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids
por: Szczurowska, Ewa, et al.
Publicado: (2022)

Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids
por: Szczurowska, Ewa, et al.
Publicado: (2022)

Neurosteroids as Selective Inhibitors of Glycine Receptor Activity: Structure-Activity Relationship Study on Endogenous Androstanes and Androstenes
por: Bukanova, Julia V., et al.
Publicado: (2020)

On the Role of Glutamate in Presynaptic Development: Possible Contributions of Presynaptic NMDA Receptors
por: Fedder, Karlie N., et al.
Publicado: (2015)

PM335. Neuroactive steroid treatment in the model of focal cerebra ischemia in immature brain
por: Vales, K., et al.
Publicado: (2016)

Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2
por: Adla, Santosh Kumar, et al.
Publicado: (2021)

Presynaptic Release-regulating Metabotropic Glutamate Receptors: An Update
por: Olivero, Guendalina, et al.
Publicado: (2020)

Neurosteroids and brain function /
Publicado: (2001)

Neuroprotective Actions of Neurosteroids
por: Borowicz, Kinga K., et al.
Publicado: (2011)

Research topic: neurosteroids
por: Vaudry, Hubert, et al.
Publicado: (2012)

Of cilia, titin, and neurosteroids
por: Adler, Elizabeth M.
Publicado: (2014)

Neurosteroids and Seizure Activity
por: Miziak, Barbara, et al.
Publicado: (2020)

Neurosteroids : a new regulatory function in the nervous system
Publicado: (1999)

Glutamate is required for depression but not potentiation of long-term presynaptic function
por: Padamsey, Zahid, et al.
Publicado: (2017)

A Glutamate Homeostat Controls the Presynaptic Inhibition of Neurotransmitter Release
por: Li, Xiling, et al.
Publicado: (2018)

Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release
por: Sigler, Albrecht, et al.
Publicado: (2017)

Neurosteroid Biosynthesis in the Brain of Amphibians
por: Vaudry, Hubert, et al.
Publicado: (2011)

Neurosteroid Influences on Sensitivity to Ethanol
por: Helms, Christa M., et al.
Publicado: (2012)

Role of hormones and neurosteroids in epileptogenesis
por: Reddy, Doodipala Samba
Publicado: (2013)

Synthetic neurosteroids on brain protection
por: Rey, Mariana, et al.
Publicado: (2015)

Neurosteroids and Focal Epileptic Disorders
por: Lévesque, Maxime, et al.
Publicado: (2020)

Impact of comorbidity scores and lifestyle factors in curative radiotherapy in laryngeal cancer
por: Pechacova, Zdenka, et al.
Publicado: (2023)

Role of Presynaptic Glutamate Receptors in Pain Transmission at the Spinal Cord Level
por: Bardoni, Rita
Publicado: (2013)

Non-canonical Mechanisms of Presynaptic Kainate Receptors Controlling Glutamate Release
por: Negrete-Díaz, José V., et al.
Publicado: (2018)

Evidence for the Association between the Intronic Haplotypes of Ionotropic Glutamate Receptors and First-Episode Schizophrenia
por: Hirschfeldova, Katerina, et al.
Publicado: (2021)

Differential Requirement for Protein Synthesis in Presynaptic Unmuting and Muting in Hippocampal Glutamate Terminals
por: Crawford, Devon C., et al.
Publicado: (2012)

Chronic inflammatory pain decreases the glutamate vesicles in presynaptic terminals of the nucleus accumbens
por: Qi, Chuchu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_99qulk98lu5375f16gt5sj3k4m